FFPE samples are the most abundant resource in cancer research, yet nucleic acid degradation makes them challenging for most sequencing assays—especially when detecting structural variants. Dovetail FFPE Services overcome this challenge.

Service details

Dovetail® FFPE Services

Advanced structural variant detection in cancer research.

How It Works

Diagram of a genomic research process showing sample collection, DNA sequencing, data analysis, results, and report generation.

The Dovetail® FFPE Service delivers ultra-sensitive structural variant detection, gene fusion discovery, and gene expression profiling—all from your FFPE sample.

Performance that Holds Up—Even in FFPE

Our SV calls demonstrate strong agreement between FFPE and fresh frozen samples, and robust performance across DIN ranges, tumor fraction and tumor types

The Dovetail® FFPE Solution

Our linked-read approach overcomes FFPE limitations, enabling:

  • Robust performance across a range of DIN scores and tumor types

  • Reproducible variant calling with high read support

  • Integrated RNA data for orthogonal gene fusion validation and expression profiling

  • Insightful results without high molecular weight DNA or specialized instrumentation

A comparison chart illustrating genomic features of three breast cancer subtypes: Sinonal Osteosarcoma, Serous Ovarian Adenocarcinoma, and IDC Breast Cancer. The chart includes data on DNA index, tumor fraction, chromosomal recall, and intra-chromosomal recall with visual circle plots of paired-end reads. A scatter plot with a correlation coefficient of 0.91 shows the relationship between FFP and fresh frozen samples.

Explore the service offering

Leverage our optimized service to uncover critical genomic alterations with unmatched confidence.

  • Confidently Detect Structural Variants. Identify structural variants with high sensitivity and specificity—even at low variant allele frequencies (VAFs).

  • Fusion Validation with Expression Context. Confirm gene fusions and assess their transcriptional impact.

  • Reliable FFPE Performance. Achieve results with high concordance to fresh frozen samples, validated across diverse tissue types.

Our Service

You provide: 11 x 5 µm scrolls (>20% tumor fraction)

We provide: Library prep and sequencing Analysis using state-of-the art proprietary pipelines Integrated variant report with SVs and gene expression profiles

Turnaround time: 10 weeks.

Your Results

  1. Raw data (FASTQ)

  2. Aligned reads (BAM)

  3. Structural Variant Calls (BEDPE)

  4. SV Cancer Relevance Summary (TSV)

  5. Gene Expression Profile and Gene Fusion Calls (TSV)

  6. Integrated HTML Report

  7. Expert support included—a dedicated project manager oversees your project and ensures smooth delivery.

Need FFPE solutions at a larger scale?

Have 100s of samples? Reach out to discuss partnership options for accessing our powerful results in your own lab.

We look forward to hearing from you!