FFPE samples are the most abundant resource in cancer research, yet nucleic acid degradation makes them challenging for most sequencing assays—especially when detecting structural variants. Dovetail FFPE Services overcome this challenge.
Dovetail® FFPE Services
Advanced structural variant detection in cancer research.
How It Works
The Dovetail® FFPE Service delivers ultra-sensitive structural variant detection—all from your FFPE sample. Dovetail Analysis supports SNV, Indel, and CNV calling—all from a single FFPE sample.
Performance that Holds Up—Even in FFPE
Our SV calls demonstrate strong agreement between FFPE and fresh frozen samples, and robust performance across DIN ranges, tumor fraction, and tumor types.
The Dovetail® FFPE Solution
Our linked-read approach overcomes FFPE limitations, enabling:
Robust performance across a range of DIN scores and tumor types
Reproducible variant calling with high read support
Insightful results without high molecular weight DNA or specialized instrumentation
Explore the service offering
Leverage our optimized service to uncover critical genomic alterations with unmatched confidence.
Confidently Detect Structural Variants. Identify structural variants with high sensitivity and specificity
Generate Comprehensive Variant Calls. Dovetail Analysis Portal supports variant analysis and provides annotated calls in easy-to-view interactive reports.
Reliable FFPE Performance. Achieve results with high concordance to fresh frozen samples, validated across diverse tissue types.
Our Service
You provide: 11 x 5 µm scrolls (>20% tumor fraction)
We provide: Library prep and sequencing Analysis using state-of-the art proprietary pipelines Integrated variant report with SVs and gene expression profiles
Turnaround time: 4 weeks.
Your Results
Raw data (FASTQ)
Aligned reads (BAM)
Structural Variant Calls (BEDPE)
Additional Variant Call Files
Integrated HTML Report
Expert support included—a dedicated project manager oversees your project and ensures smooth delivery.