Whether you are interested in species conservation, studying the intricacies of evolution or looking to improve the efficiencies of agricultural biology, the first step. Dovetail Genomics continues to be the leading provider of high quality de novo genome assembly services.

With over 900 publications, you can trust our proven kits and services to produce the highest quality, phase informed assembly possible all enabled by Dovetail’s Linked-read technology.

Genome Assembly Services

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Diploid Assembly

Despite decades of sequencing advancements, many human, plant, and animal reference genomes remain haploid because they lack phase information.

By combining shotgun sequence coverage with the ability to accurately phase SNPs genome-wide, Omni-C powers true diploid (haplotype-resolved) assemblies.

The Dovetail® Linked-Read Data powers true diploid assembly through shot-gun sequence coverage and the ability to accurately phase SNPs genome wide enabling the production of fully scaffolded haplotypes. Take advantage of our comprehensive services offerings and the expertise our services team has developed from working with hundreds of diverse taxa.

If you’d like a full de novo assembly built from scratch, we have you covered. We employ the latest and best technologies available: PacBio HiFi sequencing, for the ultimate in long-read accuracy, Dovetail’s proprietary LinkPrep™ & Omni-C proximity ligation technology and HiRise software for building contiguity up to chromosome-scale, and annotation pipeline or services so that your assembly is immediately usable.

Polyploid Assembly

Polyploids are the most challenging genomes to assemble, yet, many species of great importance to the evolution, conservation and agricultural biology communties fall into this category. Since polyploid genomes contain multiple homologous chromosomes, this makes it challening to distinguish between the different copies. Polyploid organisms can carry multiple alleles for each gene, each differing in sequence. Resolving these allelic variants accurately is critical to understanding phenotype and requires additional phasing information during the assembly process.

Due to these challenges, polyploid genome assemblies have been out of reach for all but the most experienced labs. Even then, the results commonly are unable to capture the full complexity.

Leveraging the information rich Dovetail® Linked-Read data, a datatype that captures primary sequence, long-range contacts and SNP phase information in a single sequencing run, and a state-of-the-art assembly pipeline, Dovetail® Genomics is successfully assembling genomes for a wide assortment of polyploid species.

Genome Annotation

A genome assembly is only as valuable as the biological insights it unlocks. Genome annotation, however, is complex, laborious, and time-consuming—especially without a closely related reference genome. With Dovetail® Genome Annotation Services, you can streamline this step and accelerate your understanding of the genetic blueprint underlying your study.

Explore our genome annotation partnership offering with Goenomics GMBH.

Explore past projects

Search for other genome assemblies for your species of interest or example publications.

Publications Database

  • "We are extremely happy with Dovetail’s Omni-C genome assembly of Japanese stiltgrass, now published in Genome Biology and Evolution. Invasive plant species are underrepresented among high-quality genomes, and we now have an invaluable resource for studying one of North America’s most damaging invasives. This has been a critical tool in our studies of trait variation, genomics, adaptation, and aspects of invasion biology that otherwise would have been impossible."

    Craig Barrett, West Virginia University

  • "Through the test of our several genome projects, Dovetail’s Hi-C kit has stable and excellent performance in plants, mammals and poultry. By using Dovetail Hi-C and HiRise assembly pipeline, we can obtain high-quality genomes at chromosome level. Taking eggplant as an example, we have obtained the highest quality eggplant genome so far, with contig N50=5.3 Mb and scaffold N50=93.9 Mb. In the future, we will use Dovetail’s Hi-C technology in more genome projects."

    Yongchao Niu, Biozeron Shenzhen, Inc.

  • "We have a project to sequence the genome of three Dugesia flatwom species, animals with around 2 Gbp genomes, for developing diverse studies on their evolution. The only genomes published till now for this group belong to a species from a close genus Schmidtea mediterranea for which, until very recently, only a highly fragmented genome was available. For the first two species of our project, Dovetail using PacBio and HiRise have generated a chromosome level assembly, which seems to me nearly unbelievable. I thank Dovetail for their professionality and good results. With these genomes we will be able to perform studies on chromosomal reorganizations and the effects of long-term fissiparity."

    Marta Riutort, Biodiversity Research Institute (IRBio)

  • "We sent Dovetail tissue samples and they sent us a high quality genome, with prompt and expert technical support, at a great price. Can’t ask for anything else and we’re planning to use their services again. At the Harris lab (www.fishbonelab.org) this genome will enable comparative genomics and population genetics analyses to unravel the ocean quahog’s secrets of exceptional longevity, up to 507 years."

    Stephen Treaster, Harvard Medical School