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Dovetail® Hi-C Sequencing Solutions

Dovetail Hi-C solutions all use sequence-independent nucleases to deliver high resolution and uniform base-coverage, and a novel dual cross-linking approach to enrich for long-range interactions. Our optimized, reproducible, off-the-shelf kits are validated across a wide range of samples and species and are ready to use so there’s no reagent qualification required. With our range of genomics products, it's simple to choose the best kit for your research and take your discovery to the next dimension.

Dovetail® LinkPrep™  Kit

The easiest and fastest Hi-C Kit - Period

For those seeking to add Hi-C to their toolkit or replace their current method with a faster and more cost-effective alternative, the Dovetail® LinkPrep™ Kit is the solution. Designed to simplify workflows using Tn5 technology, the LinkPrep™ assay generates superior data in less than half the time. A single-day workflow enables you to go from sample to sequence-ready library—no specialized equipment is required.

This innovative assay enables the creation of linked-read libraries for chromatin topology and highly sensitive detection of structural variants (SVs) while capturing the full range of somatic variation, including SVs, SNVs, InDels, and CNVs, all with ease. Preserving the richness of Omni-C data, the LinkPrep™ Kit delivers high-quality data for genome assembly projects with a streamlined, efficient workflow. Representing the next evolution in producing haplotype-resolved assemblies, LinkPrep™ is the ultimate combination of speed, simplicity, and exceptional data quality, seamlessly compatible with any Illumina sequencer.

Ideal For:
Genome Topology, Genetic Variation, and Genome Assembly
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Dovetail® Micro-C Kit

Get ultra-high resolution or decrease sequencing costs – it’s up to you
For those looking for fine-scale topology mapping down to the mono-nucleosome level (150 – 200 bp conformation). Unlock your genome architecture one nucleosome at a time. For those looking to save on Hi-C experiment costs. Higher signal-to-noise ratios at 1 kbp conformation resolution translates to confident matrices building at just a fraction of the cost.
Ideal For:
Non-targeted Genome Topology
Hybrid Capture Compatible

Dovetail® Pan Promoter Kit

Focus on promoter-enhancer interactions
For those looking to facilitate Hi-C studies on large sample cohorts and save sequencing costs, specifically target gene promoter regions using hybrid capture technology and map the promoter/enhancer interaction landscape.
Ideal For:
Targeted Genome Topology


Dovetail® HiChIP MNase Kit

Get a 3D take on your ChIP-seq data
For those looking to add Hi-C to your ChIP-seq. Explore how primary protein binding and protein-mediated chromatin interactions influence gene expression – in a single library. It’s ChiP-Seq, just with 3D interaction information.
Ideal For:
Protein Directed Topology
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Dovetail® Omni-C® Kit

Our original restriction enzyme free Hi-C assay

The Dovetail® Omni-C® Kit was the first kit introduced by Dovetail Genomics using a sequence-independent endonuclease to digest chromatin. This kit opened the path to haplotype resolved assemblies.

Ideal For:
Genome Assembly


Application
Application
Chromatin Topology
Whole Genome Ultra
High-Resolution Topology
Whole Genome Rapid
High-Resolution Topology
Protein Anchored Topology
Enhancer Promoter Interactions
Genetic Variation
Large Structural
Variant Detection
Genotyping
Haplotype Phasing
Genetic Genome Assembly
Genome Scafolding
Hybrid Capture Compatible
Dovetail Assay
Micro-C
TopoLink
HiChIP
Pan Promoter
VariLink
Omni-C
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* Workflow also requires the Dovetail Micro-C Kit
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