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Dovetail® Hi-C Sequencing Solutions

Dovetail Hi-C solutions all use sequence-independent nucleases to deliver high resolution and uniform base-coverage, and a novel dual cross-linking approach to enrich for long-range interactions. Our optimized, reproducible, off-the-shelf kits are validated across a wide range of samples and species and are ready to use so there’s no reagent qualification required. With our range of genomics products, it's simple to choose the best kit for your research and take your discovery to the next dimension.

Dovetail® Micro-C Kit

Get ultra-high resolution or decrease sequencing costs – it’s up to you
For those looking for fine-scale topology mapping down to the mono-nucleosome level (150 – 200 bp conformation). Unlock your genome architecture one nucleosome at a time. For those looking to save on Hi-C experiment costs. Higher signal-to-noise ratios at 1 kbp conformation resolution translates to confident matrices building at just a fraction of the cost.
Ideal For:
Non-targeted Genome Topology
Hybrid Capture Compatible

Dovetail® TopoLink™  Kit

The easiest and fastest Hi-C Kit - Period
For those looking to add Hi-C to their toolbox or replace their current Hi-C with a significantly faster and cost effective alternative, Dovetail TopoLink is the kit for you. Generate superior data in less than half the time. The Dovetail TopoPrep uses Tn5 to simplify and streamline the workflow reducing overall time without compromising data.
Ideal For:
Non-Targeted Genome Topology
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Dovetail® HiChIP MNase Kit

Get a 3D take on your ChIP-seq data
For those looking to add Hi-C to your ChIP-seq. Explore how primary protein binding and protein-mediated chromatin interactions influence gene expression – in a single library. It’s ChiP-Seq, just with 3D interaction information.
Ideal For:
Protein Directed Topology
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Dovetail® AssemblyLink™ Kit 

The easiest and fastest Hi-C kit for genome assembly on the market

Preserving the richness of the Omni-C data, but with a faster and easier workflow. The Dovetail AssemblyLink™ Kit generates Hi-C data for genome assembly projects in a single day - from sample to sequence-ready libraries. The AssemblyLink™ assay uses Tn5 to simplify and streamline the workflow, reducing overall preparation time without compromising data quality. This kit represents the next evolution for producing haplotype resolved assemblies.

Ideal For:
Genome Assembly


Dovetail® Omni-C® Kit

Our original restriction enzyme free Hi-C assay

The Dovetail® Omni-C® Kit was the first kit introduced by Dovetail Genomics using a sequence-independent endonuclease to digest chromatin. This kit opened the path to haplotype resolved assemblies.

Ideal For:
Genome Assembly

Dovetail® Pan Promoter Kit

Focus on promoter-enhancer interactions
For those looking to facilitate Hi-C studies on large sample cohorts and save sequencing costs, specifically target gene promoter regions using hybrid capture technology and map the promoter/enhancer interaction landscape.
Ideal For:
Targeted Genome Topology


Dovetail® LinkPrep™ Kit 

For Genetic Variant Detection

Generate a comprehensive whole genome view of genetic variation including structural variants, SNVs, InDels, and CNVs with high senstivity. LinkPrep technology enables your short-read sequencer to capture long-range information across the genome.

Ideal For:
Discovery of SVs, SNVs, InDels, and CNVs
Application
Application
Chromatin Topology
Whole Genome Ultra
High-Resolution Topology
Whole Genome Rapid
High-Resolution Topology
Protein Anchored Topology
Enhancer Promoter Interactions
Genetic Variation
Large Structural
Variant Detection
Genotyping
Haplotype Phasing
Genetic Genome Assembly
Genome Scafolding
Hybrid Capture Compatible
Dovetail Assay
Micro-C
TopoLink
HiChIP
Pan Promoter
VariLink
Omni-C
*
* Workflow also requires the Dovetail Micro-C Kit
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