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Dovetail® Sequencing Solutions

Dovetail linked-read technology captures long-range, Hi-C-like information on any short-read sequencer. In contrast to Hi-C, our kits deliver high resolution and uniform base-coverage through the use of non-biased enzymatic chemistry and a novel dual cross-linking approach that enriches for long-range interactions. Our optimized, reproducible, off-the-shelf kits are validated across a wide range of samples (including cells, tissue, and blood) and species. The kits are ready to use so there’s no reagent qualification required. With our range of genomics products, it's simple to choose the best kit for your research and take your discovery to the next dimension.

Dovetail® LinkPrep™  Kit

Our latest chemistry offering the easiest and fastest workflow without compromising data

For those seeking to add linked-read data to their toolkit or replace their current method with a faster and more cost-effective alternative, the Dovetail® LinkPrep™ Kit is the solution. Designed to simplify workflows using Tn5 technology, the LinkPrep™ assay generates superior data in less than half the time of Hi-C. A single-day workflow enables you to go from sample to sequence-ready library—no specialized equipment is required.

This innovative assay enables the creation of linked-read libraries for 3D genomics research and highly sensitive detection of structural variants (SVs) while capturing the full range of somatic variation, including SVs, SNVs, InDels, and CNVs, in a single assay. Additionally, the LinkPrep™ Kit delivers high-quality data for genome assembly projects with a streamlined, efficient workflow that enables the next evolution in producing haplotype-resolved assemblies. The LinkPrep™ assay offers the ultimate combination of speed, simplicity, and exceptional data quality, seamlessly compatible with any short-read sequencer.

Ideal For:
Genome Topology, Genetic Variation, and Genome Assembly
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Dovetail® Micro-C Kit

Get nucleosome resolution 3D genomic maps
For those looking for fine-scale topology mapping down to the mono-nucleosome level (150 – 200 bp conformation). Unlock your genome architecture one nucleosome at a time. Higher signal-to-noise ratios below 1 kbp conformation resolution translates to confident matrices building at just a fraction of the cost.
Ideal For:
Non-targeted Genome Topology
Hybrid Capture Compatible

Dovetail® Pan Promoter Kit

Focus on promoter-enhancer interactions
For those looking to facilitate Hi-C studies on large sample cohorts and save sequencing costs, specifically target gene promoter regions using hybrid capture technology and map the promoter/enhancer interaction landscape.
Ideal For:
Targeted Genome Topology


Dovetail® HiChIP Kit

Get a 3D take on your ChIP-seq data
For those looking to add a 3D genomic perspective to your ChIP-seq. Explore how primary protein binding and protein-mediated chromatin interactions influence gene expression – in a single library. It’s ChiP-Seq, just with 3D interaction information.
Ideal For:
Protein Directed Topology
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Dovetail® Omni-C® Kit

Our original restriction enzyme free linked-read assay

The Dovetail® Omni-C® Kit was the first kit introduced by Dovetail Genomics using a sequence-independent endonuclease to digest chromatin. This kit opened the path to haplotype resolved assemblies.

Ideal For:
Genome Assembly


Application
Genetic Variation
Large Structural
Variant Detection
Genotyping
Haplotype Phasing
Chromatin Topology
Enhancer Promoter Interactions
Whole Genome Ultra
High-Resolution Topology
Whole Genome Rapid
High-Resolution Topology
Protein Anchored Topology
Genetic Genome Assembly
Genome Scafolding
Hybrid Capture Compatible
Dovetail Assay
LinkPrep™
Micro-C
HiChIP
Pan Promoter
Omni-C
*
* Workflow also requires the Dovetail Micro-C Kit
Application
Genetic Variation
Large Structural Variant Detection Genotyping
Genotyping
Haplotype Phasing
Chromatin Topology
Targeted Enhancer-Promoter Interactions
Nucleosome-level Chromatin Topology
Whole Genome Rapid
High-Resolution Topology
Protein Anchored Topology
Genetic Genome Assembly
Genome Scaffolding
Hybrid Capture Compatible
Dovetail Assay
LinkPrep™
Micro-C
HiChIP
Pan Promoter
Omni-C
*
* Workflow also requires the Dovetail Micro-C Kit
ApplicationUseLinkPrepMicro-CHiChIPPan PromoterOmni-C
Genetic VariationLarge Structural Variant Detection



* Workflow also requires the Dovetail Micro-C Kit
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