About Cantata Bio

Dovetail Genomics is advancing genomics with Dovetail^® LinkPrep™ Technology, a powerful linked-read solution that brings long-range genomic information to standard short-read sequencing. Through a single, streamlined assay, LinkPrep™ assay enables researchers and clinicians to interrogate genome biology across scales — from SNVs, INDELs and structural variants to high-resolution 3D chromatin architecture and chromosome-scale, haplotype-resolved genome assemblies.

One Assay, Many Applications

LinkPrep™ assay powers three core areas of genomic discovery:

• Genetic Variation — Detect a broad spectrum of somatic variation, combining WGS-comparable detection of SNVs, INDELs and CNVs with high-sensitivity structural variant detection, including large and complex genomic rearrangements. Additionally, the Dovetail FFPE Assay extends these capabilities to FFPE specimens, enabling comprehensive somatic variant detection from limited and degraded material.
• 3D Genomics & Epigenetics — Generate high-resolution maps of genome organization and chromatin interactions to investigate genome architecture, including compartments, TADs and chromatin loops. Add a 3D genomic dimension to multi-omic studies by integrating LinkPrep™ data with ATAC-seq, ChIP-seq and CUT&RUN findings, providing chromatin interaction context to help connect regulatory elements to their target gene and better understand the functional relationships underlying your results.
• Genome Assembly — Rapidly generate Hi-C-like long-range information for chromosome-scale, haplotype-resolved and polyploid genome assemblies through a workflow that is automation-compatible and well suited to high-throughput environments.

More Uniform Coverage. More Genomic Insight.

Unlike traditional Hi-C approaches, where restriction-enzyme site distribution can introduce sequence bias and uneven genomic coverage, LinkPrep™ assay delivers highly uniform coverage across the genome. This improved coverage enables higher-resolution characterization of complex genomic regions and more accurate detection of structural variation and chromatin interactions — helping researchers and clinicians extract more meaningful biological information from their sequencing data.

And it does so through a streamlined, same-day wet-lab workflow, producing sequencing-ready libraries in a single day without requiring specialized expertise or sequencing platforms.

From Sample to Insight

For Genetic Variation and 3D Genomics applications, the Dovetail Analysis Portal (DAP) extends the solution beyond library preparation and sequencing to streamlined, cloud-based analysis. Supported workflows include human somatic variant calling and human and mouse epigenetic feature calling, as well as differential epigenetic analysis.

Researchers and clinicians can move directly from Dovetail linked-read FASTQ files to interactive reports and packaged, ready-to-use results — without the need to build or maintain their own bioinformatics infrastructure.

Whole-Genome or Targeted. Flexible Configuration.

Beyond its core LinkPrep™ technology, Dovetail offers a flexible portfolio of whole-genome and targeted approaches designed to match the technology to the biological question and sample.

For 3D Genomics and Epigenetics, researchers and clinicians can move from genome-wide profiling to more focused interrogation with the Dovetail^® HiChIP MNase Kit, which combines protein-targeted enrichment with MNase-based chromatin fragmentation, or with Pan Promoter enrichment, which captures promoter-anchored chromatin interactions and can be paired with either LinkPrep™ or Micro-C chemistry.

Across the broader Dovetail portfolio, solutions support a wide range of biological inputs — including blood, cells, tissues, plant material and FFPE specimens — providing researchers and clinicians with the flexibility to select the chemistry, scale and analysis approach best suited to their samples and scientific questions.