Dovetail® FFPE

Structural Variant Discovery Grant

Apply by February 27th

We are excited to announce the Dovetail®-FFPE Variant Discovery Grant, designed to help researchers uncover critical genomic alterations from FFPE samples with confidence.

Dovetail®-FFPE is a linked-read, NGS-based technology enabling high sensitivity detection of large genomic alterations such as Structural variant-driven gene fusions or non-coding chromosomal rearrangements (i.e. enhancer hijacking) from FFPE samples. Dovetail®-FFPE further enables comprehensive variant detection including SNVs, Indels and CNVs from >30X coverage data.

How does Dovetail®-FFPE work?

  • Dovetail®-FFPE is a proprietary technology uses DNA linked-reads to amplify the signal for large genomic alterations (structural variants (SVs)). This enables sensitive and robust detection of large, complex, and cryptic structural variants genome-wide.  

  • Dovetail®-FFPE technology uses unbiased fragmentation enabling superior coverage uniformity across the genome and comprehensive variant detection.

Grant winners will receive:

  • Grant winners will receive:

    • Library preparation for up to 4 FFPE samples.- FFPE samples will be processed by our Dovetail Research Experts using our proprietary Dovetail-FFPE workflow.

    • Analysis access via 4 credits to the Dovetail Analysis Portal – streamlined variant analysis through the Dovetail Variant Analysis pipeline. Analysis output includes variant call files, comprehensive summary report, and interactive portal features.

    • Full expert project management and technical support throughout the engagement

You Provide

  • 11 × 5 µm FFPE scrolls per sample

  • >20% tumor fraction

*Sequencing performed by the applicant or available for purchase through Dovetail Services

Grant Application

Dovetail FFPE Sample Structural Variant Discovery Grant

This grant is intended to support research projects with FFPE samples.

The grant covers 

  • Library preparation

  • Post sequencing analysis using state-of-the-art proprietary pipelines

  • A dedicated project manager for expert support

We are excited to receive your application!

Formalin-fixed, paraffin-embedded (FFPE) samples are the most abundant resource in oncology research—but nucleic acid degradation has long limited their utility for comprehensive sequencing, especially for detecting structural variants and gene fusions.

Our linked-read approach is purpose-built for FFPE material and delivers de novo detection of structural variants, gene fusions, and gene expression—without requiring high–molecular weight DNA or specialized instrumentation.

Key Capabilities

  • Robust performance across a wide range of DIN scores and tumor types

  • Variant calling with strong read support

  • Reliable FFPE performance, validated across diverse tissues with high concordance to fresh frozen samples

Learn more about FFPE Services