Solve your most complex genomes
Dovetail’s linked-read chemistry allows for flexible capture of both large genomic changes like translocations all the way down to single nucleotide variants. Our high resolution genomic data output uncovers somatic variations, 3D chromatin architecture, and achieves haplotype-resolved assemblies.
Explore our linked-read solutions across applications
Genome Assembly
Construct the highest resolution genome for your species of interest—including haplotype-aware, polyploid, and diploid assemblies
3D Genomics
Uncover chromatin topology with high resolution—explore unbiased WGS, loop-calling, chromatin contact maps and more
Genetic Variation
High-sensitivity detection of structural variants, SNVs, InDels, and CNVs – completing your view of genetic variation
Linked-reads for
Watch the LinkPrep technology overview for 3D genomics applications.
One data type for all your chromatin research questions
A complete solution—sample to sequence to insight, we have you covered with our team of support scientists and our bioinformatics portal.
What is a linked-read?
Linked-read is a term for any genomic sequencing output that has additional oligo information. Dovetail Genomics’ linked-read assays are similar to Hi-C—connecting positional DNA-DNA relationships to sequencing data through proximity ligation oligo sequences to provide spatial information about the DNA in the nucleus.
Why Dovetail linked-read?
Our linked-read libraries types overcome the linear limitations of other short-read approaches to enable capture of long-range chromatin information with short range oligo sequences. The flexibility of short range sequences with long range information enables high resolution genomes with haplotype resolution, detection of de novo somatic variants (SNV, InDel, CNV) and unbiased resolution of 3D genomic interactions—without sacrificing sequencing depth or data quality.
Featured Product
Featured Product
Dovetail® LinkPrep™ technology generates high-quality linked-read libraries that preserve long-range genomic information, enabling powerful insights across a wide range of applications—including comprehensive somatic variant detection, 3D genome mapping, and haplotype-aware genome assemblies
Why Dovetail Genomics?
A legacy of solving complex genomes
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Founded in 2013, Dovetail Genomics pioneered chromatin interaction (linked-read) technology to advance genome assembly. Our innovations started with genome assembly—in vitro proximity ligation assay and HiRise™ pipeline enabled reference-grade assemblies for diverse organisms. Over time, Dovetail expanded into 3D genomics and kit-based solutions, delivering enzyme-free linked-read methods and tools for structural variant discovery that now drive breakthroughs in cancer and translational research.
