Dovetail^®LinkPrep™ Kit

Accelerate Your Linked-Read Library Prep

Ideal For:

Genetic Variation, 3D Genomics, and Genome Assembly

Dovetail^®LinkPrep™ Technology Video

A brief overview of our innovative LinkPrep™ technology, highlighting its versatile applications, streamlined and easily integrated workflow, validated sample types, and standout features!

One Assay, Multiple Solutions

Watch Here

Do More with a Single Assay, In Less Time

SNV, Haplotype phasing, indel, cnv, 3d genomics

Dovetail® LinkPrep™ technology generates high-quality linked-read libraries that preserve long-range genomic information, enabling powerful insights across a wide range of applications—including comprehensive variant detection, 3D genome mapping, and haplotype-aware genome assemblies.

Designed for simplicity and speed, the Dovetail® LinkPrep™ Kit includes all the critical components needed to produce sequencer-compatible libraries in a single-day workflow.

Uniform Coverage Across The Genome

LinkPrep™ technology delivers improved genome coverage and data quality compared to traditional short-read sequencing approaches. The enhanced signal-to-noise ratio (green curve) underscores the assay’s ability to achieve higher resolution and more accurate detection of structural variations and chromatin interactions. This capability offers a clearer understanding of complex genomic regions, enabling you to extract more meaningful insights from your data.

Now Compatible with Hybrid Capture

The Dovetail® LinkPrep™ Assay now supports hybrid capture. When paired with the Dovetail® Pan Promoter Panel, targeted LinkPrep™ data enables efficient promoter-anchored interaction profiling and enriches biologically meaningful signals, revealing connections between promoters, regulatory elements, and non-coding variants.

This powerful approach can accelerate research in GWAS, oncology, and 3D genomics. Whether you're using our Pan Promoter Panel, an off-the-shelf third-party panel, or your own custom design, targeting LinkPrep interactions delivers high-quality data, streamlined analysis, and scalability—all while maintaining the speed, accuracy, and affordability of the core assay.

An Integrated Solution

Dovetail^® LinkPrep™ technology expands the capabilities of short-read sequencers to capture long-range genetic information. It enables base pair-resolved genetic variation detection, high-resolution 3D genome characterization, and rapid haplotype-aware assemblies. Utilizing standard NGS workflows, the LinkPrep™ Assay generates linked-read data, enhancing sensitivity and improving accuracy across a broad range of applications to advance your research.

Leverage Existing Resources

Customer Testimonials

"Our lab is excited about the potential of LinkPrep™ data. We currently use a range of NGS-based assays to catalog genetic variations spanning from SNVs up to large SVs. LinkPrep™ has the potential to become a key tool in our oncology research, offering powerful capabilities for the de novo detection of the full spectrum of somatic variants that we focus on."

Brian Walker, Ph.D.

Professor of Medical and Molecular Genetics at Indiana University School of Medicine
"We're thrilled to onboard the Dovetail LinkPrep™ kit. The Minderoo OceanOmics Centre at UWA is using Dovetail Hi-C preps to scaffold whole genome assemblies of marine vertebrate species, as we create a comprehensive library of high-quality reference genomes. The refined workflow will decrease hands-on time in the lab and increase sequencing throughput. The reduced input requirements from fresh frozen animal tissue means we can now tackle even the smallest specimens without compromising sequencing quality or complexity."

Adrianne Doran,

Scientific Officer, Minderoo OceanOmics Centre at UWA
"We are very excited by the capabilities of the LinkPrep™ kit. It takes just one day to go from sample preparation to sequencing for a novel de novo assembly or for high-resolution 3D genomic interactions. This efficiency will have a great impact, cutting down the process from three days to one without compromising on deliverables. At the Australian Genome Research Facility, where we strive to provide premium customer services, we can't wait to test it further."

Dr. Dhanya Sooraj, Senior Scientist

Innovation and Development, Australian Genome Research Facility