Dovetail^® Micro-C Kit

Ideal For:

Non-targeted Genome Topology

Capture the full breadth of chromatin topology with a genome wide approach producing the most extensive view of 3D chromatin architecture.

Interested in enhancer-promoter interactions. Reduce your sequencing cost and boost your signal-to-noise by focusing just those interactions occurring at known gene promoters using Dovetail’s purpose-built hybrid capture pan promoter panel.

Want to customize your focus? Dovetail® Micro-C libraries are compatible with standard and custom hybrid capture panels from other sources.

The MNase Advantage

The Dovetail Micro-C Kit uses micrococcal nuclease (MNase) to generate highly uniform fragments that uniquely capture nucleosome positioning information while still maintaining an even coverage across the genome. The benefit is increased mapping resolution aligned with the unit of chromatin, that is, the nucleosome.

Unlock the 3D genome architecture at the nucleosome level and start discovering the epigenetic answers you’ve been looking for.

Reduce Sequencing Burden

The ability to detect higher-order features, such as chromatin loops, in proximity ligation data is dependent on enriching long-range informative reads to capture chromatin interaction frequency. The Dovetail Micro-C Kit only requires 800 M reads to get 1 kb matrices compared to the 1.2-1.6 billion reads required by restriction enzyme-based Hi-C methods. Translation? Significant sequencing savings for you.