Dovetail Products and Services have become synonymous with industry leading genome assembly, epigenetics and variant detection solutions. Our linked-read NGS solutions use sequence-independent nucleases to deliver the highest resolution and most uniform base-coverage, and a novel dual cross-linking approach to maximize capture of long-range interactions.
The Dovetail®Workflow
The Dovetail®Difference
Traditional Hi-C uses restriction enzymes to fragment the chromatin. Due to the non-random distribution of restriction enzyme cut sites, this introduces bias into the data resulting in uneven read coverage and signal shifting. Dovetail approaches eliminate this bias by using sequence independent fragmentation approaches.
Capture More of the Genome
Highly uniform coverage of the genome overcomes sequence gaps present in traditional Hi-C data due to low restriction site density.
Benefit: Capture more information across more of the genome.
More Accurately Capture Biology
Traditional Hi-C is biased by restriction enzyme motif location, which can distort identified features. Use of sequence independent enzymes eliminates this bias.
Benefit: More accurate calling of genomic features such as chromatin topology.
Reduce Experimental Cost
Unsurpassed signal-to-noise reduces sequencing cost and requires less sample compared to traditional Hi-C.
Benefit: Significant savings on sequencing and sample preparation costs without compromising experimental discoveries.
Scaleable Analytics
Self serve and full-service options built on years of experience working with 3D genomics data. Our analytic solutions scale to the needs of any lab.
Benefit: Fuel your research with actionable biological insights.
