Dovetail^® Proximity Ligation

Dovetail Products and Services have become synonymous with industry leading genome assembly, epigenetics and variant detection solutions. Our proximity ligation solutions use sequence-independent nucleases to deliver the highest resolution and most uniform base-coverage, and a novel dual cross-linking approach to maximize capture of long-range interactions.

Traditional Hi-C uses restriction enzymes to fragment the chromatin. Due to the non-random distribution of restriction enzyme cut sites, this introduces bias into the data resulting in uneven read coverage and signal shifting. Dovetail approaches eliminate this bias by using sequence independent fragmentation approaches.